Please take caution with supplements and consult with your doctor. Neither Andrew nor us are responsible for what you decide to do
We included all the studies and references at the bottom for you to read more about each supplement
Rationale
Dr. Andrew Huberman believes that behavioral tools and nutrition form the foundation for mental and physical health. Supplements should only be used to support them.
Before taking supplements, consider cost. Ask yourself three questions: How is your sleep? How is your nutrition? What is your budget? Single-ingredient formulated supplements are more effective for specific needs.
If the budget is limited, focus on foundational nutrition, adaptogens, probiotics, prebiotics, and digestive enzymes. Athletic greens is an example of such a supplement.
Foundational for Health
Omega 3s
1 gram of EPAs per day
Vitamin D
5,000 to 10,000IU of vitamin D per day
Selium
Can get this with 3 brazilian nuts per day
For cognitive function
- Alpha-GPC – 300 mg daily.
- Choline - 500mg daily
can be attained with eggs and butter
- Glutamine
Huperzine A
For motivation
- L-Tyrosine – 500 mg daily
- L carnitine - for motivation
- Phenylethylamine (PEA) – 500 mg daily
For sleep
- Magnesium L-Threonate – 140 mg daily.
- Theanine – 100-300 mg daily.
- Apigenin – 50 mg daily
For increasing testosterone
- Tongkat Ali – 400 mg taken daily.
- Fadogia Agrestis – 425 mg to 600 mg taken daily
- Zinc - 120mg taken twice per day
For Stress
Vitamin B6 after high-pressure seasons
• Ashwagandha – 500 mg.
Other
Yerba mate
Increases GLP1 and helps you focus
Arginine
Arginine taken in pill form or IV: 3g -10g
Increases growth hormone by 100%-600%
Caution if you have high blood pressure or cardiac problems
Nicotine gum or patches
Effects of nicotine
- triggers the release of dopamine and increases levels
- increases attention, focus, and concentration
- increases alertness and arousal
- Suppresses appetite
Do not smoke. Do not vape.
Athletic Greens
Cannabis (negative)
4x likelier to develop a chronic, major depression
Causes disruptions in mood, anxiety, fertility,and mental health
Even worse for young, developing brains
Creatine Monohydrate
5 grams - daily
For every glass of alcohol, drink 2 glasses of water with electrolytes to offset some negative effects
To minimize the effects of a hangover, it's ideal to have proper electrolyte levels before drinking alcohol
For Hair Loss
Minoxidil, Tadalafil, Platelet-rich plasma (PRP) injections, microneedling, and Botox.
For Fertility
When trying a new supplement, try one at a time to observe its effects. Women seeking fertility and hormone support should take single-ingredient supplements to adjust dosages based on the menstrual cycle phase.
References
List curated from fastlifehacks.com
- Tongkat Ali (Eurycoma longifolia Jack): A review on its ethnobotany and pharmacological importance – Karim et al. | Fitoterapia | 2010
- Mode of cellular toxicity of aqueous extract of Fadogia agrestis (Schweinf. Ex Hiern) stem in male rat liver and kidney – Yakubu et al. | 2009 | Human & Experimental Toxicology
- The causes of adverse changes of testosterone levels in men – Wrzosek et al. | 2020 | Expert Review of Endocrinology & Metabolism Journal
- Effect of Zinc on Testosterone Levels and Sexual Function of Postmenopausal Women: A Randomized Controlled Trial – Nia et al. | 2021 | Journal of Sex & Marital Therapy
- Comparative absorption of zinc picolinate, zinc citrate and zinc gluconate in humans | Barrie et al. | 1987 | Bioinorganic Interaction
- Magnesium in man: implications for health and disease – Bindels et al. | 2015 | Physiological Reviews
- Long-term HRV analysis shows stress reduction by magnesium intake – Nolden et al. | RCT, n=100 | 2016 | MMW – Fortschritte der Medizin
- Perspective: The Case for an Evidence-Based Reference Interval for Serum Magnesium: The Time Has Come | Costello et al. | 2016 | Advances in Nutrition
- Theanine consumption, stress and anxiety in human clinical trials: A systematic review – Naumovski | Meta-review | 2016 | Journal of Nutrition & Intermediary Metabolism.
- L-theanine, a natural constituent in tea, and its effect on mental state – Owen et al. | 2008 |Asia Pacific Journal of Clinical Nutrition
- The cellular language of myo- inositol signaling | 2011 | Glenda E. Gillaspy
- Effects of Oral Gamma-Aminobutyric Acid (GABA) Administration on Stress and Sleep in Humans: A Systematic Review – Hepsomali et al. (2020) | Frontiers in Science
- Gamma-aminobutyric acid as a bioactive compound in foods: a review – Diana et al. (2014) | Journal of Functional Foods
- New Therapeutic Strategy for Amino Acid Medicine: Glycine Improves the Quality of Sleep – Bannai et al. (2012) | Journal of Pharmacological Sciences
- Source for 600 mg being his upper limit, see 1hr 41m 14s of Dr. Andy Galpin: Optimal Nutrition & Supplementation for Fitness
- Association of L-α Glycerylphosphorylcholine With Subsequent Stroke Risk After 10 Years – Lee et al. (2021) JAMA Neurology
- Essential fatty acids and human brain – Chen et al. | Acta Neurologica Taiwan | 2009
- Metabolism of α-linolenic acid in humans – G.C. Burdge | (see section 7.2 of paper) | 2006 | Journal: PLEFA
- Metabolism of α-linolenic acid in humans – G.C. Burdge | (see section 7.2 of paper) | 2006 | Journal: PLEFA
- Blood docosahexaenoic acid and eicosapentaenoic acid in vegans: Associations with age and gender and effects of an algal-derived omega-3 fatty acid supplement – Sarter et al. | 2014 | Clinical Nutrition
- Blood docosahexaenoic acid and eicosapentaenoic acid in vegans: Associations with age and gender and effects of an algal-derived omega-3 fatty acid supplement – Sarter et al. | 2014 | Clinical Nutrition
- The Roles of Glutamine in the Intestine and Its Implication in Intestinal Diseases | Kim et al. | 2017 | International Journal of Molecular Sciences
- Why Is L-Glutamine Metabolism Important to Cells of the Immune System in Health, Postinjury, Surgery or Infection? | Newsholme | 2001 | The Journal of Nutrition
- The Possible Importance of Glutamine Supplementation to Mood and Cognition in Hypoxia from High Altitude | Quaresma et al. | 2020 | Nutrients Journal
- Vitamin D: A Micronutrient Regulating Genes – Carsten Carlberg | 2019 | Current Pharmaceutical Design
- A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults – Chandrasekhar et al. | 2012 | Indian Journal of Psychological Medicine
- Age-Associated Changes In Oxidative Stress and NAD Metabolism In Human Tissue – Massudi et al. | 2012 | PLoS ONE Journal
- Gut Microbiota-Dependent Marker TMAO in Promoting Cardiovascular Disease: Inflammation Mechanism, Clinical Prognostic, and Potential as a Therapeutic Target – Yang et al. | 2019 | Frontiers in Pharmacology
- Effects of L-carnitine supplementation on oxidative stress and antioxidant enzymes activities in patients with coronary artery disease: a randomized, placebo-controlled trial – Lee et al. | 2014 | Nutrition Journal | See references 4 to 9
- The effect of Cissus quadrangularis (CQR-300) and a Cissus formulation (CORE) on obesity and obesity-induced oxidative stress – Oben et al. (2007) | Lipids in Health and Disease
- Nicotine and sympathetic neurotransmission – Haass & Kübler | 1997 | Cardiovascular Drugs and Therapy Journal
- Effects and applications of arthropod steroid hormones (ecdysteroids) in mammals – Dinan et al. | 2006 | Journal of Endocrinology
- Ecdysteroids as non-conventional anabolic agent: performance enhancement by ecdysterone supplementation in humans – Isenman et al. | 2019 | Archives of Toxicology
- Tongkat Ali (Eurycoma longifolia Jack): A review on its ethnobotany and pharmacological importance – Karim et al. | Fitoterapia | 2010
- Mode of cellular toxicity of aqueous extract of Fadogia agrestis (Schweinf. Ex Hiern) stem in male rat liver and kidney – Yakubu et al. | 2009 | Human & Experimental Toxicology
- The causes of adverse changes of testosterone levels in men – Wrzosek et al. | 2020 | Expert Review of Endocrinology & Metabolism Journal
- Effect of Zinc on Testosterone Levels and Sexual Function of Postmenopausal Women: A Randomized Controlled Trial – Nia et al. | 2021 | Journal of Sex & Marital Therapy
- Comparative absorption of zinc picolinate, zinc citrate and zinc gluconate in humans | Barrie et al. | 1987 | Bioinorganic Interaction
- Magnesium in man: implications for health and disease – Bindels et al. | 2015 | Physiological Reviews
- Long-term HRV analysis shows stress reduction by magnesium intake – Nolden et al. | RCT, n=100 | 2016 | MMW – Fortschritte der Medizin
- Perspective: The Case for an Evidence-Based Reference Interval for Serum Magnesium: The Time Has Come | Costello et al. | 2016 | Advances in Nutrition
- Theanine consumption, stress and anxiety in human clinical trials: A systematic review – Naumovski | Meta-review | 2016 | Journal of Nutrition & Intermediary Metabolism.
- L-theanine, a natural constituent in tea, and its effect on mental state – Owen et al. | 2008 |Asia Pacific Journal of Clinical Nutrition
- The cellular language of myo- inositol signaling | 2011 | Glenda E. Gillaspy
- Effects of Oral Gamma-Aminobutyric Acid (GABA) Administration on Stress and Sleep in Humans: A Systematic Review – Hepsomali et al. (2020) | Frontiers in Scienc
- Gamma-aminobutyric acid as a bioactive compound in foods: a review – Diana et al. (2014) | Journal of Functional Foods
- New Therapeutic Strategy for Amino Acid Medicine: Glycine Improves the Quality of Sleep – Bannai et al. (2012) | Journal of Pharmacological Sciences
- Source for 600 mg being his upper limit, see 1hr 41m 14s of Dr. Andy Galpin: Optimal Nutrition & Supplementation for Fitness
- Association of L-α Glycerylphosphorylcholine With Subsequent Stroke Risk After 10 Years – Lee et al. (2021) JAMA Neurology
- Essential fatty acids and human brain – Chen et al. | Acta Neurologica Taiwan | 2009
- Metabolism of α-linolenic acid in humans – G.C. Burdge | (see section 7.2 of paper) | 2006 | Journal: PLEFA
- Metabolism of α-linolenic acid in humans – G.C. Burdge | (see section 7.2 of paper) | 2006 | Journal: PLEFA
- Blood docosahexaenoic acid and eicosapentaenoic acid in vegans: Associations with age and gender and effects of an algal-derived omega-3 fatty acid supplement – Sarter et al. | 2014 | Clinical Nutrition
- Blood docosahexaenoic acid and eicosapentaenoic acid in vegans: Associations with age and gender and effects of an algal-derived omega-3 fatty acid supplement – Sarter et al. | 2014 | Clinical Nutrition
- The Roles of Glutamine in the Intestine and Its Implication in Intestinal Diseases | Kim et al. | 2017 | International Journal of Molecular Sciences
- Why Is L-Glutamine Metabolism Important to Cells of the Immune System in Health, Postinjury, Surgery or Infection? | Newsholme | 2001 | The Journal of Nutrition
- The Possible Importance of Glutamine Supplementation to Mood and Cognition in Hypoxia from High Altitude | Quaresma et al. | 2020 | Nutrients Journal
- Vitamin D: A Micronutrient Regulating Genes – Carsten Carlberg | 2019 | Current Pharmaceutical Design
- A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults – Chandrasekhar et al. | 2012 | Indian Journal of Psychological Medicine
- Age-Associated Changes In Oxidative Stress and NAD Metabolism In Human Tissue – Massudi et al. | 2012 | PLoS ONE Journal
- Gut Microbiota-Dependent Marker TMAO in Promoting Cardiovascular Disease: Inflammation Mechanism, Clinical Prognostic, and Potential as a Therapeutic Target – Yang et al. | 2019 | Frontiers in Pharmacology
- Effects of L-carnitine supplementation on oxidative stress and antioxidant enzymes activities in patients with coronary artery disease: a randomized, placebo-controlled trial – Lee et al. | 2014 | Nutrition Journal | See references 4 to 9
- The effect of Cissus quadrangularis (CQR-300) and a Cissus formulation (CORE) on obesity and obesity-induced oxidative stress – Oben et al. (2007) | Lipids in Health and Disease
- Nicotine and sympathetic neurotransmission – Haass & Kübler | 1997 | Cardiovascular Drugs and Therapy Journal
- Effects and applications of arthropod steroid hormones (ecdysteroids) in mammals – Dinan et al. | 2006 | Journal of Endocrinology
- Ecdysteroids as non-conventional anabolic agent: performance enhancement by ecdysterone supplementation in humans – Isenman et al. | 2019 | Archives of Toxicology